Cell-targeting aptamers act as intracellular delivery vehicles.
Identifieur interne : 000335 ( Main/Exploration ); précédent : 000334; suivant : 000336Cell-targeting aptamers act as intracellular delivery vehicles.
Auteurs : Subash C B. Gopinath [Malaisie] ; Thangavel Lakshmipriya [Malaisie] ; Yeng Chen [Malaisie] ; M K Md Arshad [Malaisie] ; Jesinda P. Kerishnan [Malaisie] ; A R Ruslinda [Malaisie] ; Yarub Al-Douri [Malaisie, Algérie] ; C H Voon [Malaisie] ; Uda Hashim [Malaisie]Source :
- Applied microbiology and biotechnology [ 1432-0614 ] ; 2016.
Descripteurs français
- KwdFr :
- MESH :
- génétique : Transport biologique.
- métabolisme : Aptamères nucléotidiques, Marqueurs biologiques, Vecteurs de médicaments.
- Humains, Technique SELEX.
English descriptors
- KwdEn :
- MESH :
- chemical , metabolism : Aptamers, Nucleotide, Biomarkers, Drug Carriers.
- genetics : Biological Transport.
- Humans, SELEX Aptamer Technique.
Abstract
Aptamers are single-stranded nucleic acids or peptides identified from a randomized combinatorial library through specific interaction with the target of interest. Targets can be of any size, from small molecules to whole cells, attesting to the versatility of aptamers for binding a wide range of targets. Aptamers show drug properties that are analogous to antibodies, with high specificity and affinity to their target molecules. Aptamers can penetrate disease-causing microbial and mammalian cells. Generated aptamers that target surface biomarkers act as cell-targeting agents and intracellular delivery vehicles. Within this context, the "cell-internalizing aptamers" are widely investigated via the process of cell uptake with selective binding during in vivo systematic evolution of ligands by exponential enrichment (SELEX) or by cell-internalization SELEX, which targets cell surface antigens to be receptors. These internalizing aptamers are highly preferable for the localization and functional analyses of multiple targets. In this overview, we discuss the ways by which internalizing aptamers are generated and their successful applications. Furthermore, theranostic approaches featuring cell-internalized aptamers are discussed with the purpose of analyzing and diagnosing disease-causing pathogens.
DOI: 10.1007/s00253-016-7686-2
PubMed: 27350620
Affiliations:
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Gopinath</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Nano Electronic Engineering, Universiti Malaysia Perlis, 01000, Kangar, Perlis, Malaysia. subash@unimap.edu.my.</nlm:affiliation><country xml:lang="fr">Malaisie</country><wicri:regionArea>Institute of Nano Electronic Engineering, Universiti Malaysia Perlis, 01000, Kangar, Perlis</wicri:regionArea><wicri:noRegion>Perlis</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>School of Bioprocess Engineering, Universiti Malaysia Perlis, 02600, Arau, Perlis, Malaysia. subash@unimap.edu.my.</nlm:affiliation><country xml:lang="fr">Malaisie</country><wicri:regionArea>School of Bioprocess Engineering, Universiti Malaysia Perlis, 02600, Arau, Perlis</wicri:regionArea><wicri:noRegion>Perlis</wicri:noRegion></affiliation></author><author><name sortKey="Lakshmipriya, Thangavel" sort="Lakshmipriya, Thangavel" uniqKey="Lakshmipriya T" first="Thangavel" last="Lakshmipriya">Thangavel Lakshmipriya</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Nano Electronic Engineering, Universiti Malaysia Perlis, 01000, Kangar, Perlis, Malaysia.</nlm:affiliation><country xml:lang="fr">Malaisie</country><wicri:regionArea>Institute of Nano Electronic Engineering, Universiti Malaysia Perlis, 01000, Kangar, Perlis</wicri:regionArea><wicri:noRegion>Perlis</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Yeng" sort="Chen, Yeng" uniqKey="Chen Y" first="Yeng" last="Chen">Yeng Chen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Oral Biology and Biomedical Sciences, Faculty of Dentistry, University of Malaya, 50603, Kuala Lumpur, Malaysia.</nlm:affiliation><country xml:lang="fr">Malaisie</country><wicri:regionArea>Department of Oral Biology and Biomedical Sciences, Faculty of Dentistry, University of Malaya, 50603, Kuala Lumpur</wicri:regionArea><wicri:noRegion>Kuala Lumpur</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Oral Cancer Research and Coordinating Center, Faculty of Dentistry, University of Malaya, 50603, Kuala Lumpur, Malaysia.</nlm:affiliation><country xml:lang="fr">Malaisie</country><wicri:regionArea>Oral Cancer Research and Coordinating Center, Faculty of Dentistry, University of Malaya, 50603, Kuala Lumpur</wicri:regionArea><wicri:noRegion>Kuala Lumpur</wicri:noRegion></affiliation></author><author><name sortKey="Arshad, M K Md" sort="Arshad, M K Md" uniqKey="Arshad M" first="M K Md" last="Arshad">M K Md Arshad</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Nano Electronic Engineering, Universiti Malaysia Perlis, 01000, Kangar, Perlis, Malaysia.</nlm:affiliation><country xml:lang="fr">Malaisie</country><wicri:regionArea>Institute of Nano Electronic Engineering, Universiti Malaysia Perlis, 01000, Kangar, Perlis</wicri:regionArea><wicri:noRegion>Perlis</wicri:noRegion></affiliation></author><author><name sortKey="Kerishnan, Jesinda P" sort="Kerishnan, Jesinda P" uniqKey="Kerishnan J" first="Jesinda P" last="Kerishnan">Jesinda P. Kerishnan</name><affiliation wicri:level="1"><nlm:affiliation>Department of Oral Biology and Biomedical Sciences, Faculty of Dentistry, University of Malaya, 50603, Kuala Lumpur, Malaysia.</nlm:affiliation><country xml:lang="fr">Malaisie</country><wicri:regionArea>Department of Oral Biology and Biomedical Sciences, Faculty of Dentistry, University of Malaya, 50603, Kuala Lumpur</wicri:regionArea><wicri:noRegion>Kuala Lumpur</wicri:noRegion></affiliation></author><author><name sortKey="Ruslinda, A R" sort="Ruslinda, A R" uniqKey="Ruslinda A" first="A R" last="Ruslinda">A R Ruslinda</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Nano Electronic Engineering, Universiti Malaysia Perlis, 01000, Kangar, Perlis, Malaysia.</nlm:affiliation><country xml:lang="fr">Malaisie</country><wicri:regionArea>Institute of Nano Electronic Engineering, Universiti Malaysia Perlis, 01000, Kangar, Perlis</wicri:regionArea><wicri:noRegion>Perlis</wicri:noRegion></affiliation></author><author><name sortKey="Al Douri, Yarub" sort="Al Douri, Yarub" uniqKey="Al Douri Y" first="Yarub" last="Al-Douri">Yarub Al-Douri</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Nano Electronic Engineering, Universiti Malaysia Perlis, 01000, Kangar, Perlis, Malaysia.</nlm:affiliation><country xml:lang="fr">Malaisie</country><wicri:regionArea>Institute of Nano Electronic Engineering, Universiti Malaysia Perlis, 01000, Kangar, Perlis</wicri:regionArea><wicri:noRegion>Perlis</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Physics Department, Faculty of Science, University of Sidi-Bel-Abbes, Sidi-Bel-Abbes, 22000, Algeria.</nlm:affiliation><country xml:lang="fr">Algérie</country><wicri:regionArea>Physics Department, Faculty of Science, University of Sidi-Bel-Abbes, Sidi-Bel-Abbes, 22000</wicri:regionArea><wicri:noRegion>22000</wicri:noRegion></affiliation></author><author><name sortKey="Voon, C H" sort="Voon, C H" uniqKey="Voon C" first="C H" last="Voon">C H Voon</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Nano Electronic Engineering, Universiti Malaysia Perlis, 01000, Kangar, Perlis, Malaysia.</nlm:affiliation><country xml:lang="fr">Malaisie</country><wicri:regionArea>Institute of Nano Electronic Engineering, Universiti Malaysia Perlis, 01000, Kangar, Perlis</wicri:regionArea><wicri:noRegion>Perlis</wicri:noRegion></affiliation></author><author><name sortKey="Hashim, Uda" sort="Hashim, Uda" uniqKey="Hashim U" first="Uda" last="Hashim">Uda Hashim</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Nano Electronic Engineering, Universiti Malaysia Perlis, 01000, Kangar, Perlis, Malaysia.</nlm:affiliation><country xml:lang="fr">Malaisie</country><wicri:regionArea>Institute of Nano Electronic Engineering, Universiti Malaysia Perlis, 01000, Kangar, Perlis</wicri:regionArea><wicri:noRegion>Perlis</wicri:noRegion></affiliation></author></analytic><series><title level="j">Applied microbiology and biotechnology</title><idno type="eISSN">1432-0614</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aptamers, Nucleotide (metabolism)</term><term>Biological Transport (genetics)</term><term>Biomarkers (metabolism)</term><term>Drug Carriers (metabolism)</term><term>Humans (MeSH)</term><term>SELEX Aptamer Technique (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Aptamères nucléotidiques (métabolisme)</term><term>Humains (MeSH)</term><term>Marqueurs biologiques (métabolisme)</term><term>Technique SELEX (MeSH)</term><term>Transport biologique (génétique)</term><term>Vecteurs de médicaments (métabolisme)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Aptamers, Nucleotide</term><term>Biomarkers</term><term>Drug Carriers</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Biological Transport</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Transport biologique</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Aptamères nucléotidiques</term><term>Marqueurs biologiques</term><term>Vecteurs de médicaments</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term><term>SELEX Aptamer Technique</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Humains</term><term>Technique SELEX</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Aptamers are single-stranded nucleic acids or peptides identified from a randomized combinatorial library through specific interaction with the target of interest. Targets can be of any size, from small molecules to whole cells, attesting to the versatility of aptamers for binding a wide range of targets. Aptamers show drug properties that are analogous to antibodies, with high specificity and affinity to their target molecules. Aptamers can penetrate disease-causing microbial and mammalian cells. Generated aptamers that target surface biomarkers act as cell-targeting agents and intracellular delivery vehicles. Within this context, the "cell-internalizing aptamers" are widely investigated via the process of cell uptake with selective binding during in vivo systematic evolution of ligands by exponential enrichment (SELEX) or by cell-internalization SELEX, which targets cell surface antigens to be receptors. These internalizing aptamers are highly preferable for the localization and functional analyses of multiple targets. In this overview, we discuss the ways by which internalizing aptamers are generated and their successful applications. Furthermore, theranostic approaches featuring cell-internalized aptamers are discussed with the purpose of analyzing and diagnosing disease-causing pathogens. </div></front></TEI><affiliations><list><country><li>Algérie</li><li>Malaisie</li></country></list><tree><country name="Malaisie"><noRegion><name sortKey="Gopinath, Subash C B" sort="Gopinath, Subash C B" uniqKey="Gopinath S" first="Subash C B" last="Gopinath">Subash C B. Gopinath</name></noRegion><name sortKey="Al Douri, Yarub" sort="Al Douri, Yarub" uniqKey="Al Douri Y" first="Yarub" last="Al-Douri">Yarub Al-Douri</name><name sortKey="Arshad, M K Md" sort="Arshad, M K Md" uniqKey="Arshad M" first="M K Md" last="Arshad">M K Md Arshad</name><name sortKey="Chen, Yeng" sort="Chen, Yeng" uniqKey="Chen Y" first="Yeng" last="Chen">Yeng Chen</name><name sortKey="Chen, Yeng" sort="Chen, Yeng" uniqKey="Chen Y" first="Yeng" last="Chen">Yeng Chen</name><name sortKey="Gopinath, Subash C B" sort="Gopinath, Subash C B" uniqKey="Gopinath S" first="Subash C B" last="Gopinath">Subash C B. Gopinath</name><name sortKey="Hashim, Uda" sort="Hashim, Uda" uniqKey="Hashim U" first="Uda" last="Hashim">Uda Hashim</name><name sortKey="Kerishnan, Jesinda P" sort="Kerishnan, Jesinda P" uniqKey="Kerishnan J" first="Jesinda P" last="Kerishnan">Jesinda P. Kerishnan</name><name sortKey="Lakshmipriya, Thangavel" sort="Lakshmipriya, Thangavel" uniqKey="Lakshmipriya T" first="Thangavel" last="Lakshmipriya">Thangavel Lakshmipriya</name><name sortKey="Ruslinda, A R" sort="Ruslinda, A R" uniqKey="Ruslinda A" first="A R" last="Ruslinda">A R Ruslinda</name><name sortKey="Voon, C H" sort="Voon, C H" uniqKey="Voon C" first="C H" last="Voon">C H Voon</name></country><country name="Algérie"><noRegion><name sortKey="Al Douri, Yarub" sort="Al Douri, Yarub" uniqKey="Al Douri Y" first="Yarub" last="Al-Douri">Yarub Al-Douri</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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